Lysin Products: Preventing and Treating Bacterial Issues Utilizing Best or First-in-Class Lysins Systems
Lysigen Lead Products - Treatments for Lung and Skin Infections:
Precisio is developing a suite of lysin products to treat both gram positive and gram negative lung infections. The Company expects to be able to achieve a minimum of a 3 log reduction of each of the targeted bacterial pathogens.
Eczema is a chronic, recurrent and inflammatory skin disease related to allergic reactions. Traditionally eczema is thought of as an autoimmune disease. However, skin colonization with Staphylococcus aureus plays an important role. In different studies 54-100% of atopic dermatitis patients were colonized with Staphylococcus aureus. It is also well established that the prevalence of Staphylococcus aureus increases during AD flares. Our lead product is a best-in-class staph lysin to topically treat Staphylococcus aureus infections associated with eczema.
Acne (vulgaris) is a chronic skin disease of the pilosebaceous unit and develops due to blockages in the skin's hair follicles. These blockages occur as a result of the following abnormal processes: increased oily sebum production, excessive deposition of the protein keratin, colonization of the follicle by Cutibacterium acnes (C. acnes) bacteria, and the resultant pro-inflammatory reactions in the skin. In addition, S. aureus is also reported to play an important role in the pathogenesis of acne. Our First-in-Class C.acnes Lysin + ClyO product precisely target these causative bacteria in order to treat acne.