Lysins, Amurins and Phages
Lysins, Amurins and Phages – Effective Biological Antibacterial Solutions
Bacteriophages are parasitic viruses that kill with precision the bacteria they infect. The bacteriophage initially infects the target cell and begins reproducing inside of it. Once the new phages are mature, they typically utilize a lysin enzyme to burst out of the cell, thereby killing it. Phages continue to multiply only so long as the pathogen remains present.
Lysins are enzymes that degrade cell walls of target bacteria. In recombinantly produced and purified forms, lysins can kill target bacteria when added "from without" in the absence of any phage particles. Precisio is capable of the rapid, cost-effective creation some of the world's best recombinant lysins, engineered for extremely potent activity. Instead of lysins, some rare bacteriophage instead use amurin peptides, which are also bacteriolytic in their purified forms.
Phage, Lysin and Amurin Life-Cycle
lysins, amurins and phages are superior to conventional antibiotics in the following ways:
- Exceptionally specific: Kill targeted bacteria only. Do not harm the biome or natural bacterial flora.
- Lysins and amurins cause no bacterial resistance: No resistance has been observed; for phages, resistance is difficult if engineered effectively. Phages have almost no resistance if cocktails are created effectively.
- Typically, faster-acting than antibiotics: Lysins and amurins can kill on contact.
- Penetrate biofilm and kill biofilm-associated bacteria, and also kill most persister cells.
- Synergistic with most existing treatments: Can suppress resistance to other agents and resensitize antibiotic-resistant bacteria.
